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Hypersensitive esophagus

In certain patients, symptoms of GERD can occur even with minimal or no acid exposure. Such patients also typically do not respond to medicines. The reason for this is increased sensitivity of the esophageal lining. The reason for such sensitivity is not exactly known. 

The diagnosis can be made on 24 hour pH monitoring (discussed subsequently).

Due to presence of very effective medicines that decrease the acid, such hypersensitivity is now a common reason for persistent symptoms despite treatment.

The hypersensitivity can lie in the nerves supplying the esophagus or within the brain.

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